周玉

教师姓名：周玉

出生年月：1969.01

职称职务：教授

最高学位：博士

研究方向：食品和水环境安全

招生方向：083200食品科学与工程；095135食品加工与安全

办公电话：

电子邮箱：zhouyurunye@sina.com

个人简介：周玉，国家食品药品监督管理局食品安全专家，教育部学位与研究生教育发展中心-全国研究生教育评估监测专家，四川轻化工大学学科带头人，博士生导师。致力于食品和水环境中有害分子的超灵敏、高通量、快速检测新方法研究。

研究领域及主要成果：食品和水环境中有害分子检测新方法。涉及到的靶标物包括重金属、中毒性生物毒素、多环芳烃及农兽药残留等。在纳米探针的设计合成（DNA探针、金纳米抗体探针、金纳米酶探针、磁纳米抗体探针等）、小分子靶标物检测信号增敏策略挖掘、复杂基质检测体系创建等免疫学检测新方法的基础研究方面已取得系列突破性进展。

主持国家自然科学基金面上项目6项，四川省科-教联合重点项目1项，吉林省科技项目2项；获吉林省科学技术进步奖二等奖1项，全国商业科技进步奖一等奖1项；在Biosen. Bioelectron.和Food Chem.等国际权威SCI期刊以第一作者/通讯作者发表SCI论文90余篇（唯一第一作者兼唯一通讯作者发表SCI论文31篇），他引总次数3000余次。研究成果被美国、德国、日本等30多个国家和地区的数百位同行广泛引用、借鉴、专题评述和正面评价，并开展了系列跟踪和拓展研究。

主持代表课题：

1. 国家自然科学基金委员会，面上项目，32272411，基于SiO₂纳米探针和贵金属纳米粒子局域表面等离子共振（LSPR）双重信号增敏的真菌毒素高灵敏免疫检测研究，2023-01至2026-12。

2. 国家自然科学基金委员会，面上项目，31871888，基于磁纳米微球和金纳米粒子双探针介导的有机磷农药（OPs）检测技术研究，2019-01至2022-12。

3. 国家自然科学基金委员会，面上项目，61571208，纳米金粒子介导的复合探针的设计合成及其在多环芳烃分析检测中的应用研究，2016-01至2019-12。

4. 国家自然科学基金委员会，面上项目，61171022，基于多价免疫生物传感器的原料乳中多种蛋白高通量检测新方法研究，2012-01至2015-12。

5. 国家自然科学基金委员会，面上项目，60971011，基于重组抗体的水环境中痕量重金属高通量检测技术研究，2010-01至2012-12。

6. 国家自然科学基金委员会，面上项目，30771657，以广谱单链抗体（ScFv）为探针筛检水环境及水产品中中毒性藻毒素，2008-01至2010-12。

7. 科技部重点研发计划项目，2017YFD0501302，畜禽重要人兽共患寄生虫病源头防控与阻断技（任务主持），2017-01至2020-12。

8. 科技部重点研发计划项目，2018YFC1602505，食品中生物毒素特异性增敏检测与非靶向确证技术研发（任务主持），2019-01至2021-12。

9. 四川省科-教联合基金重点项目，2025NSFSC2020，四重级联信号增敏的粮谷类酿酒原料中真菌毒素超灵敏检测新方法，2025-05至2028-04。

10. 吉林省科技厅项目，20170101192JC，食品中荧蒽、芘免疫层析试纸条的研制，2017-01至2019-12。

11. 吉林省科技厅项目，20140101012JC，基于抗体-酶双标记纳米金的食品及水环境多环芳烃检测技术研究，2014-01至2016-12。

代表论文：近五年（2022年以来），以第一作者/通讯作者身份发表SCI论文37篇（中科院一区18篇、二区17篇）：

[1] Naiyu Guan, Weizhen Xu, Shanghong Ji, Tingtiao Pan, Jing Zhu, Ki Soo Park, Yu Zhou. Gold-tetrahedron DNA nanoflare probe-based fluorescent immunoassay for glyphosate detection. Sensors & Actuators: B. Chemical 453 (2026) 139537.

[2] Shanghong Ji, Tingtiao Pan, Weizhen Xu, Song Tang, Guodong Mu, Zeyu Hu, Yu Zhou. Dual-readout digital colorimetric assay for zearalenone in corn based on alkaline phosphatase mediated growth of Prussian blue nanoparticles. Food Chemistry 503 (2026) 147766.

[3] Weizhen Xu, Jinwei Hu, Haiyang Liang, Nuoyu Liu, Yu Zhou, Zhifeng Zhao. Construction of an effective colorimetric and fluorescent dual-mode microneedle patch for non-destructive detection of nitrite in pickling foods. Biosens. Bioelectron. 287 (2025) 117744.

[4] Wang Chen, Yanan Zhao, Die Xu, Zhenzhen Luo, Shanghong Ji, Weizhen Xu, Yu Zhou. Dual-competition mediated ratiometric fluorescent immunoassay for detection of ochratoxin A. Food Chemistry 495 (2025) 146437.

[5] Yingli Guo, Xingping Zhang, Hualin Yang, Yu Zhou. Triple-readout immunoassay based on copper ion trigger for the detection of ochratoxin A. Anal. Chim. Acta 1345 (2025) 343750.

[6] Xin Yang, Yuanyuan Wang, Xiaowei Chen, Yujun Feng, Yingli Guo, Hualin Yang, Yu Zhou. Dual-mode detection of Ochratoxin A based on silver nanocluster and phosphate. Food Chem.,474 (2025) 143131

[7] Xiaowei Chen, Yujun Feng, Yuanyuan Wang, Xin Yang, Xingping Zhang, Hualin Yang, Yu Zhou. Colorimetric and fluorescence dual-mode detection of Oxytetracycline based on Hemin/G-quadruplex DNAzyme and ZIF-8. Food Control 168 (2025) 110942

[8] Xingping Zhang, Bin Qiao, Yansong Li, Yu Zhou, Hualin Yang. Multi-wavelength and multicolor immunoassay for sensitive detection of fluorene based on silver deposition on the surface of gold nanorods. ‌Microchem. J‌., 213 (2025) 113912.

[9] Yuanyuan Wang, Xin Yang, Xiaowei Chen, Yujun Feng, Yingli Guo, Yu Zhou, Hualin Yang. Manganese dioxide nanosheets triggered fluorescence and colorimetric dual-mode immunoassay for detection of Ochratoxin A. Food Control 170 (2025) 111045

[10] Yonghong Zha, Yansong Li, Jianhua Zhou, Xiaolan Liu, Ki Soo Park, Yu Zhou. Dual-Mode Fluorescent/Intelligent Lateral Flow Immunoassay Based on Machine Learning Algorithm for Ultrasensitive Analysis of Chloroacetamide Herbicides. Anal. Chem. 2024, 96, 12197−12204.

[11] Xiaolong Zheng, Linlin Sun, Yanan Zhao, Hualin Yang, Yuanhua Zhu, Junxiang Zhang, Die Xu, Xingping Zhang, Yu Zhou. A fluorescence and colorimetric dual-mode immunoassay for detection of ochratoxin a based on cerium nanoparticles. ‌Microchem. J‌., 201 (2024) 110419.

[12] Linlin Sun, Xiaolong Zheng, Hualin Yang, Yuanhua Zhu, Junxiang Zhang, Xingping Zhang, Yu Zhou. A ratiometric fluorescence immunoassay based on Ce⁴⁺ oxidized o-phthalylenediamine and polyvinylpyrrolidone protected copper nanoclusters for the detection of aflatoxin B1. ‌Microchem. J‌., 206 (2024) 111427.

[13] Shixiang Wu, Yanan Zhao, Yao Xiao, Liyuan Ma, Qi Zhang, Peiwu Li, Hualin Yang, Yu Zhou. Dual-readout immunoassay based on IFE and p-phenylenediamine for detection of zearalenone. J. Food Compos. Anal., 132 (2024) 106311.

[14] Yanan Zhao, Wang Chen, Huajuan Fang, Junxiang Zhang, Shixiang Wu, Hualin Yang, Yu Zhou. Ratiometric fluorescence immunoassay based on silver nanoclusters and calcein-Ce3+ for detecting ochratoxin A. Talanta 269 (2024) 125470.  

[15] Die Xu, Junxiang Zhang, Zhenzhen Luo, Yanan Zhao, Yuanhua Zhu, Hualin Yang, Yu Zhou. Ratiometric fluorescence and absorbance dual-model immunoassay based on 2,3-diaminophenazine and carbon dots for detecting Aflatoxin B1. Food Chem.,439 (2024) 138125

[16] Yuanhua Zhu, Yanan Zhao, Hualin Yang, Jing Ma, Xiaolong Zheng, Junxiang Zhang, Die Xu, Xingping Zhang, Yu Zhou. Dual-readout colorimetric immunoassay based on halogenated indophenol for rapid detection of aflatoxin B1. ‌Microchem. J‌., 197 (2024) 109741

[17] Yu Zhou, Yansong Li, Xiaoqian Tang, Hui Li, Qi Zhang, Ki Soo Park, Peiwu Li. A dual-signal output plasmonic sensor based on glucose oxidase-triggered etching of triangular silver nanoprism for sensitive detection of fumonisins. ‌Microchem. J‌., 196 (2024) 109713.

[18] Junxiang Zhang, Die Xu, Zhenzhen Luo, Yanan Zhao, Xiaolong Zheng, Hualin Yang, Yu Zhou. Gold nanoparticle-mediated fluorescence immunoassay for rapid and sensitive detection of Ochratoxin A. Spectrochim. Acta Part A 304 (2024) 123312.

[19] Xiaolong Zheng, Yanan Zhao, Yan Zhang, Yuanhua Zhu, Junxiang Zhang, Die Xu, Hualin Yang, Yu Zhou. Alkaline phosphatase triggered gold nanoclusters turn-on fluorescence immunoassay for detection of Ochratoxin A. Spectrochim. Acta Part A 304 (2024) 123317

[20] Zhenzhen Luo, Junxiang Zhang, Jing Ma, Die Xu, Yanan Zhao, Yuanhua Zhu, Hualin Yang, Yu Zhou. Fluorescence and absorbance dual-mode immunoassay for detection of Ochratoxin A based on 2-aminoterephthalic acid and p-nitrophenol. J. Food Compos. Anal.125 (2024) 105784

[21] Liyuan Ma, Xingping Zhang, Yao Xiao, Huajuan Fang, Guohao Zhang, Hualin Yang, Yu Zhou. Fluorescence and colorimetric dual-mode immunoassay based on G-quadruplex/N-methylmesoporphyrin IX and p-nitrophenol for detection of zearalenone. Food Chem.,401 (2023) 134190.

[22] Shixiang Wu, Xingping Zhang, Wang Chen, Guohao Zhang, Qian Zhang, Hualin Yang, Yu Zhou. Alkaline phosphatase triggered ratiometric fluorescence immunoassay for detection of zearalenone. Food Control 146 (2023) 109541.

[23] Ning Xu, Yan Liu, Yansong Li, Bin Tang, Chen Li, Mingyuan Liu, Yu Zhou, Xiaolei Liu. Dual-functional AuNP-triggered hybridization chain reaction for enhanced competitive immunosensing for Trichinella spiralis antibody in zoonosis screening. Sensors Actuator B: Chem., 379 (2023)133300.

[24] Guohao Zhang, Xingping Zhang, Qian Zhang, Wang Chen, Shixiang Wu, Hualin Yang, Yu Zhou. MnO₂ nanosheets-triggered oxVB1 fluorescence immunoassay for detection zearalenone. Spectrochim. Acta Part A 286 (2023) 121954.

[25] Qian Zhang, Xingping Zhang, Guohao Zhang, Wang Chen, Shixiang Wu, Hualin Yang, Yu Zhou. Multicolor immunosensor for detection of zearalenone based on etching Au NBPs mediated by HRP. J. Food Compos. Anal.115 (2023) 105014.

[26] Huajuan Fang, Xingping Zhang, Liyuan Ma, Yao Xiao, Hualin Yang, Yu Zhou. Fluorescence detection of glyphosate based on G-quadruplex and porphyrin metalation. J. Food Compos. Anal.,116 (2023) 105074.

[27] Liyuan Ma, Xingping Zhang, Yu Peng, Wang Chen, Yao Xiao, Huajuan Fang, Hualin Yang, Yu Zhou. Based on intervening PCR for detection of alkaline phosphatase and zearalenone. ‌Microchem. J‌.186 (2023) 108314.

[28] Yao Yu, Yansong Li, Ning Xu, Yonghong Zha, Xue Bai, Mingyuan Liu, Yu Zhou, Xiaolei Liu. Fluorescence ratio immunoassay for fumonisin B1 based on the oxidase characteristics of the growth of monodispersed 2D MnO₂ nanosheet on an individual gold nanoparticle (AuNP@MnO₂). Microchim. Acta (2023) 190: 93.

[29] Wang Chen, Xingping Zhang, Qian Zhang, Guohao Zhang, Shixiang Wu, Hualin Yang, Yu Zhou. Cerium ions triggered dual-readout immunoassay based on aggregation induced emission effect and 3,3′,5,5′-tetramethylbenzidine for fluorescent and colorimetric detection of ochratoxin A. Anal. Chim. Acta 1231 (2022) 340445.

[30] Yao Yu, Yansong Li, Qi Zhang, Yonghong Zha, Shiying Lu, Yong Yang, Peiwu Li, Yu Zhou. Colorimetric immunoassay via smartphone based on Mn2+-Mediated aggregation of AuNPs for convenient detection of fumonisin B1. Food Control 132 (2022) 108481.

[31] Huajuan Fang; Xingping Zhang; Dongxu Gao; Yao Xiao; Liyuan Ma; Hualin Yang; Yu Zhou. Fluorescence determination of glyphosate based on a DNA‑templated copper nanoparticle biosensor. Microchim. Acta (2022) 189:158.

[32] Cuiling Shang; Yansong Li; Qi Zhang; Song Tang; Xiaoqian Tang; Honglin Ren; Pan Hu; Shiying Lu; Peiwu Li; Yu Zhou. Alkaline phosphatase-triggered dual-signal immunoassay for colorimetric and electrochemical detection of zearalenone in cornmeal. Sensors Actuators B: Chem‌ 358 (2022) 131525.

[33] Yu Peng, Mingming Xu, Yushuang Guo, Hualin Yang, Yu Zhou. A novel signal amplification biosensor for detection of Cd²⁺ based on asymmetric PCR. Spectrochim. Acta Part A 271 (2022) 120885.

[34] Yu Peng; Mingming Xu; Hualin Yang; Yu Zhou. A double signal amplification strategy for sensitive detection of Hg²⁺ based on exonuclease III and PCR. Spectrochimica Acta Part A: Spectrochim. Acta Part A 271 (2022) 120957.

[35] Mingming Xu; Yu Peng; Hualin Yang; Yu Zhou. Highly sensitive biosensor based on aptamer and hybridization chain reaction for detection of cadmium ions. Luminescence 2022, 37 (4), 665-671.

[36] Yao Xiao, Xingping Zhang, Liyuan Ma, Huajuan Fang, Hualin Yang, Yu Zhou. Fluorescence and absorbance dual-mode immunoassay for detecting Ochratoxin A. Spectrochim. Acta Part A 279 (2022) 121440

[37] Xingping Zhang, Jiujun Wang, Hualin Yang, and Yu Zhou. A Novel Biosensor for Detecting Vitamin C in Milk Powder Based on Hg²⁺-Mediated DNA Structural Changes. Current Analytical Chemistry, 2022, 18, 845-851.

授权发明专利：

用于检测伏马毒素B1的试剂盒及检测方法（CN 113341131 B）

一种农产品中赭曲霉毒素A的检测方法（CN 116698806 B）

一种基于PCR检测汞离子的方法（CN 113088564 B）

一种碱性磷酸酶的检测方法（CN 113758909 B）

一种磷酸根离子的检测方法（CN 113406052 B）