
导师姓名:谢浩
职称职务:讲师
最高学位:博士学位
研究方向:微生物学,合成生物学
办公电话:15606826899
电子邮箱:xiehaosg@suse.edu.cn
个人简介:
谢浩,理学博士,讲师。
教育经历:
2012.09-2016.06,南京农业大学,农学,本科;
2016.08-2018.06,瑞典乌普萨拉大学(Uppsala University),生物学,硕士;
l2019.05-2024.11,瑞典乌普萨拉大学(Uppsala University),微生物化学,博士。
工作经历:
2025.01-至今,四川轻化工大学食品与酿酒工程学院,讲师。
研究方向:
- 合成生物学元件开发及代谢通路重构
- 蓝藻生理生化特性与分子调控机制研究
- 高附加值天然产物合成途径解析与绿色生物制造技术研究
主讲课程:
本科课程:《生物化学》、《生化实验技术》
代表论文:
1. Xie H, Begum A, Gunn LH, Lindblad P. Directed evolution of α-ketoisovalerate decarboxylase for improved isobutanol and 3-methyl-1-butanol production in cyanobacteria. Biotechnol Biofuels Bioprod 2025, 18:84.
2. Xie H, Bourgade B, Stensjö K, Lindblad P. dCas12a-mediated CRISPR interference for multiplex gene repression in cyanobacteria for enhanced isobutanol and 3-methyl-1-butanol production. Microb Cell Fact 2025, 24:104.
3. Xie H, Kjellström J, Lindblad P. Sustainable production of photosynthetic isobutanol and 3-methyl-1-butanol in the cyanobacterium Synechocystis sp. PCC 6803. Biotechnol Biofuels 2023, 16:134.
4. Xie H, Lindblad P. Expressing 2-keto acid pathway enzymes significantly increases photosynthetic isobutanol production. Microb Cell Fact 2022, 21:17.
5. Bourgade B, Xie H, Lindblad P, Stensjö K. Development of a CRISPR activation system for targeted gene upregulation in Synechocystis sp. PCC 6803. Commun Biol 2025, 8:772.
6. Liu XF, Xie H, Roussou S, Lindblad P. Current advances in engineering cyanobacteria and their applications for photosynthetic butanol production. Curr Opin Biotechnol 2022, 73:143-150.
7. Miao R, Xie H, Ho F, Lindblad P. Protein engineering of α-ketoisovalerate decarboxylase for improved isobutanol production in Synechocystis PCC 6803. Metab Eng 2018, 47:42-48.
8. Miao R, Xie H, Lindblad P. Enhancement of photosynthetic isobutanol production in engineered cells of Synechocystis PCC 6803. Biotechnol Biofuels Bioprod 2018, 11:267.
代表著作:
1. Xie H, Fuller S, Liu XF, Lindblad P. 2025. Technologies for enhanced photosynthetic butanol production. In: Renewable butanol: Fermentation, Process Technology and Biofuel Applications (Editor: Friedl A et al.) Chapter 11, accepted. John Wiley & Sons (Hoboken, NJ, USA).
2. Xie H, Kukil K, Lindberg P, Miao R, Lindblad P. 2022. Metabolic rewiring and cultivation optimization for photosynthetic biofuel production in cyanobacteria. In: Bio-Clean Energy Technologies: Volume 1, Clean Energy Production Technologies (Editor: Pankaj Chowdhary et al.) Chapter 3, pages 45–80. Springer (Singapore).
3. Liu X, Xie H, Roussou S, Miao R and Lindblad, P. 2021. Engineering cyanobacteria for photosynthetic butanol production. In: Photosynthesis: Light conversion for biotechnological applications with microalgae (Editor: Rögner, M.) Chapter 2, pages 33-56. De Gruyter (Berlin/München).
代表课题与专利:
1. 2025年度四川省留学回国人员科技活动项目择优资助项目,以蓝藻(集胞藻)为底盘细胞生产绿色生物燃料的研究,主持。
2. 四川轻化工大学人才引进项目,高效合成伪枝藻素蓝细菌新底盘构建,2025-2027,主持。
3. 四川省科技厅自然科学基金重点项目,以蓝藻为底盘细胞智造胞外甜味蛋白的研究,2025-2028,参与。
4. 受理发明专利:一种重组质粒、构建方法及其在提高发菜伪枝藻素合成能力中的应用,申请号202511075495.9。
